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. 2023 Oct 25;24:252. doi: 10.1186/s12931-023-02563-7

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 5 — circP4HB can bind to PKM2. A circP4HB is mainly located in the cytoplasm. B RIP assay showed circP4HB can bind to circP4HB. CircP4HB can regulate the expression of PKM2 in transcriptional level (C, D) but protein level (E). F Western blot confirmed the interaction between PKM2 and circP4HB after pull down (*p < 0.05, ***p < 0.001)