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. 2023 Oct 25;24:252. doi: 10.1186/s12931-023-02563-7

Fig. 7.

Fig. 7

circP4HB promotes M2 macrophage polarization through PKM2. A The results of western bolt showed circP4HB can significantly increase the formation of tetrameric PKM2. In vivo crosslinking was performed by incubating the cells with 1 mM disuccinimidyl suberate (DSS) at room temperature for 30 min B the schematic diagram of co-culture between THP1 cells and LUAD cells. C the results of M2 macrophage markers (CD206/CCL18/IL10/Arg). (*p < 0.05, **p < 0.01, ***p < 0.001, ****p < 0.0001, NS, no significance)