TABLE 4.
The effect of levofloxacin, rifampin, and erythromycin, at 10 times their MICs, used singly and in combination against Legionella pneumophila L-1033 (pH 6.0)
| Antibiotic (concn, μg/ml) | Bacterial killing (log10 CFU/ml)a on assay day:
|
|||
|---|---|---|---|---|
| 1 | 2 | 3 | 4 | |
| Control | 1.13 | 1.23 | 1.41 | 1.07 |
| Levofloxacin (0.3) | 0.47 | 0.53 | 0.18 | 0.12 |
| Rifampin (0.01) | 0.40 | 0.35 | 0.36 | −0.12 |
| Erythromycin (5.0) | 0.60 | 0.36 | 0.48 | 0.64 |
| Levofloxacin (0.3) plus rifampin (0.01) | 0.40 | 0.08 | 0.27 | −0.26 |
| Levofloxacin (0.3) plus erythromycin (5.0) | 0.45 | 0.22 | 0.30 | −0.06 |
| Rifampin (0.01) plus erythromycin (5.0) | 0.58 | 0.52 | 0.84 | 0.07 |
See Table 1, footnote a. SEM range for controls and for antibiotic-containing assays is 0.22 to 0.40.