Table 6.
Overview of toxicity profile across 8 studies
| Reference No. | Patients, N | Salivary gland toxicity (xerostomia) | Hematologic toxicity | Nephrotoxicity/renal failure | ||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| haemoglobin/anaemia | WBC count/leukopenia | platelets/thrombocytopenia | ||||||||||||||
| grade I and II | grade III | grade IV | grade I and II | grade III | grade IV | grade I and II | grade III | grade IV | grade I and II | grade III | grade IV | grade I and II | grade III | grade IV | ||
| [13] | 40 | Severe xerostomia-15 | Intolerable xerostomia-4 | NR | NR | NR | NR | NR | NR | NR | NR | NR | NR | NR | NR | NR |
| [14] | 17 | 17 | 0 | 0 | NR | 1 | 0 | NR | NR | NR | NR | NR | NR | NR | 0 | 1 |
| [15] | 73 | 62 | 0 | 0 | 22 | 5 | 0 | 7 | 2 | 0 | 6 | 1 | 0 | 18 | 3 | 2 |
| [16] | 28 | 8 | 0 | 0 | 27 | 1 | 0 | 11 | 0 | 0 | 4 | 0 | 0 | 4 | 0 | 0 |
| [17] | 18 | 13 | 0 | ND | 11 | 3 | 0 | 4 | 1 | 0 | 6 | 0 | 0 | 2 | 0 | 0 |
| [18] | 11 | 8 | 1 | 0 | 8 | 1 | 0 | 5 | 0 | 0 | 5 | 2 | 0 | 1 | 1 | 0 |
| [19] | 26 | 26 | 0 | ND | 6 | 8 | 1 | 6 | 7 | 0 | 9 | 3 | 2 | 5 | 0 | 0 |
| [20] | 13 | 13 | 0 | 0 | NR | 0 | 0 | NR | 0 | 0 | NR | 0 | 0 | NR | 0 | 0 |
NR, not reported; ND, not defined.