. 2023 Mar 22;32(3):200–208. doi: 10.1159/000529863

Table 3.

TIMI major bleeding and secondary outcomes according to sex

	Women (n = 1,172)	Men (n = 3,087)	p value^a
Outcome at discharge
TIMI major bleeding	16 (1.4)	21 (0.7)	0.057
Bleeding class
Access site bleeding	7 (0.6)	3 (0.1)	0.006
GI bleeding	2 (0.2)	5 (0.2)	0.98
Intracranial bleeding	0 (0.0)	3 (0.1)	0.27
Other bleeding	7 (0.6)	10 (0.3)	0.25
Combined ischemic endpoint^b	17 (1.5)	32 (1.0)	0.56
MI	5 (0.4)	17 (0.6)	0.48
CV death	26 (2.2)	79 (2.6)	0.30
Death	31 (2.6)	87 (2.8)	0.47
Outcome at 30 days
TIMI major bleeding	19 (1.6)	30 (1.0)	0.075
Bleeding class
Access site bleeding	8 (0.7)	4 (0.1)	0.002
GI bleeding	3 (0.3)	9 (0.3)	0.85
Intracranial bleeding	1 (0.1)	6 (0.2)	0.43
Other bleeding	7 (0.6)	11 (0.4)	0.28
Combined ischemic endpoint^b	20 (1.7)	46 (1.5)	0.61
MI	6 (0.5)	23 (0.7)	0.41
CV death	29 (2.5)	88 (2.9)	0.51
Death	35 (3.0)	96 (3.1)	0.84
Outcome at 1 year
TIMI major bleeding	31 (2.6)	48 (1.6)	0.018
Bleeding class
Access site bleeding	11 (0.9)	4 (0.1)	<0.001
GI bleeding	5 (0.4)	16 (0.5)	0.70
Intracranial bleeding	3 (0.3)	13 (0.4)	0.43
Other bleeding^c	12 (1.0)	15 (0.5)	0.048
Combined ischemic endpoint^b	39 (3.3)	91 (2.9)	0.52
MI	13 (1.1)	55 (1.8)	0.12
CV death	44 (3.8)	106 (3.4)	0.62
Death	61 (5.2)	132 (4.3)	0.20

Categorical variables are presented as counts and percentages.

TIMI, thrombolysis in myocardial infarction; GI, gastrointestinal; CV, cardiovascular.

^aKaplan-Meier estimates, log-rank (Mantel-Cox).

^bComposite of myocardial infarction, stent thrombosis, and ischemic stroke.

^cOther bleedings included pericardial effusion (n = 9), posttraumatic bleeding (including post-resuscitation [n = 3]), postoperative bleeding (n = 2), epistaxis (n = 1), spleen bleeding (n = 1), bleeding due to dislocation of wire (n = 1), or bleedings with unknown origin (n = 10).