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. 2023 Oct 17;16(10):dmm050085. doi: 10.1242/dmm.050085

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© 2023. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 4. — Influence of JAK2 inhibition on removal of the epithelial seam in culture. (A,B) Hematoxylin and Eosin staining confirmed the morphological differences between control and AG490-treated palates. (A) Control palates are completely fused. (B) In AG490-treated palates, the MEE (black arrowheads) persists in the midline of the secondary palate. (C) The fusing rate of secondary palatal shelves in control and AG490-treated mice. (D-G) p63 immunoreactivity in the MEE almost disappeared in the midline of the secondary control palate (D,E), whereas p63-immunoreactive MEE (white arrowheads in G) was retained in the AG490-treated palate (F,G). (E,G) Higher-magnification views of the boxed areas in D and F, respectively. (H) In controls, K17-immunoreactive periderm was sparsely observed in the epithelial remnants in the midline between the bilateral palatal shelves. (I) In AG490-treated palates, K17-immunoreactive periderms were retained at the epithelial seam (white arrowheads). Scale bars: 40 μm.