Figure 2: rCNV-associated risk of psychiatric disorders in the iPSYCH2105 case-cohort.

rCNV-associated Hazard ratios (HR) and 95% confidence intervals (CI95%) were derived from Cox proportional hazards (CPH) models using inverse probability of sampling (IPS) weights, and are indicated for deletions and duplications by red and blue colour, respectively, for the 18 rCNV loci assessed in this study. Associated HRs with P<0.05 (i.e. with CI95% not overlapping HR=1) are bolded, and loci are ordered on the y-axis from top to bottom by decreasing sum LOEUF score²⁸. Abbreviations for the four most common psychiatric disorders targeted by the iPSYCH2015 case-cohort design (depicted on plot) are as follows: ADHD; attention-deficit hyperactivity disorder, ASD; autism spectrum disorder, MDD; major depressive disorder, SSD; schizophrenia spectrum disorder. Full per-locus results, including estimates also for Schizophrenia (SCZ), bipolar disorder (BPD), any affective disorder (AFF), any iPSYCH disorder (ANY), intellectual disability (ID) and epilepsy, are provided in Extended Data Figure 2.