Figure 4: Contrasts in associated risk by dosage change across rCNV loci.

Hazard ratios (HR) with error bars indicating standard errors (SE) for deletions and duplications are plotted on the x-axis and y-axis, respectively for ADHD, ASD and SSD. The 16 loci with available HR estimates for both deletions and duplications for at least one diagnosis are indicated by different colours (see figure legend) corresponding to previous figures. The dashed line indicates risk parity. We found no evidence of a locus-by-dosage interaction increasing prediction of case status in an omnibus test across all loci and diagnoses between a GEE model with the interaction term and a nested model without the interaction term (likelihood ratio test; P=0.16).