TABLE 1.

Pharmacokinetic parameters derived from fitting the two-compartment model (Fig. 1) simultaneously to the serum concentrations after intravenous administration and oral administration of lamivudine (at one of six dose levels) in 52 HIV-infected children

Parameter	Vc (liter/kg)	kcel (h−1)	kcp (h−1)	kpc (h−1)	ka (h−1)
Geometric mean	0.362	1.37	1.22	1.06	0.899
Median	0.395	1.32	1.55	1.25	0.850
First to third quartiles	0.292–0.505	0.959–1.71	0.808–2.68	0.710–2.27	0.535–1.27
Range	0.081–1.11	0.545–5.41	0.050–6.89	0.054–7.77	0.121–9.93