TABLE 3.
Concentration of lamivudine in CSFa
| Dose level (mg/kg) | No. of patients | No. of CSF samples | Concn of lamivudine in CSF (μM)b | % CSF drug concn to serum drug concnc |
|---|---|---|---|---|
| 0.5 | 5 | 8 | 0.07 (UD–0.12) | 13 (0–22) |
| 1 | 7 | 10 | 0.12 (UD–0.16) | 17 (0–46) |
| 2 | 8 | 13 | 0.23 (0.08–0.35) | 10 (6–21) |
| 4 | 9 | 14 | 0.31 (0.06–1.44) | 11 (3–31) |
| 6 | 9 | 14 | 0.59 (0.06–1.99) | 12 (3–31) |
| 10 | 6 | 9 | 0.99 (0.32–2.23) | 10 (6–22) |
a
The concentration was measured in 68 CSF samples from 44 patients.
b
Expressed as median (range). UD, undetectable.
c
Derived after dividing the CSF drug concentration by the simultaneously measured serum drug concentration.