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[Preprint]. 2023 Oct 4:rs.3.rs-3270539. [Version 1] doi: 10.21203/rs.3.rs-3270539/v1

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(A) CREB1 signaling activator Fsk (left) (10um for 24hr in LNCaP cells) and with ISO (right) (15um for 24hr in PC3 cells) activates p-S133-CREB1 and induces bulk H3K27me3 levels. (B) p-S133-CREB1 and H3K27me3 levels are induced in PC3 cells expressing constitutively activated CREB1-Y134F mutant cDNA. (C) CREB1 signaling inhibitor PKI (left) (10um for 24hr in 144-13 cells) and with ICI (right) (10um for 24hr in NE1.3 cells) reduces p-S133-CREB1 and bulk H3K27me3 levels.