Table 1.

Inclusion and exclusion criteria

Inclusion Criteria	Exclusion Criteria
Age between 4–65 at enrollment	Any other illness that would interfere with the ability to undergo safe testing or would interfere with interpretation of the results in the opinion of the site investigator
Clinically affected (defined as weakness on bedside evaluation in either a limb-girdle pattern or in a distal extremity)
Genetically or functionally confirmed mutation in ANO5, CAPN3, DYSF, SGCA-G, or DNAJB6	History of Bleeding disorder Platelet count < 50,000 Current use of an anticoagulant
Willing and able to give informed consent and follow all study procedures and requirements	Positive pregnancy test at any time point during the trial