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[Preprint]. 2023 Oct 20:rs.3.rs-3446917. [Version 1] doi: 10.21203/rs.3.rs-3446917/v1

Figure 4. Functional properties of selected PIT-matching and non-matching TRA chains of known specificity.

Figure 4

A) Dose response curves for TCRs recognizing GAD65, IGRP and ZNT8 epitopes 13. Curves for multiple epitopes per target antigen were pooled to increase power; examination of curves for individual epitopes yielded conclusions consistent with the pooled data. B) Cross-reactivity of TCRs with PIT-matching TRA junctions (Table 3) for autoimmune (GAD65) and viral (influenza M protein) epitopes in a CFSE proliferation assay.