Table 2.
TCRs sharing single mismatched TRA chains between PIT and IAR T cells of known specificity. A
| TRA chain | TRB chain | |||||
|---|---|---|---|---|---|---|
| specificity | V gene | Junction | J gene | V gene | Junction | J gene |
| GADp15 | TRAV41 | CAAA-GNQFYF | TRAJ49 | TRBV12-4 | CASSFT-YNEQFF | TRBJ2-1 |
| TRAV29/DV5 B | CAAR-GNQFYF | TRAJ49 | TRBV6-2 | CASSLLNLDNEQFF | TRBJ2-1 | |
| TRAV21 | CAAI-GNQFYF | TRAJ49 | TRBV29-1 | CSVLRDRASYEQYF | TRBJ2-7 | |
| TRAV29/DV5 | CAASAGNQFYF | TRAJ49 | TRBV4-1 | CASSLAATRDDYGYTF | TRBJ1-2 | |
| IGRP39 | TRAV25 | CAGQTGANNLFF | TRAJ36 | TRBV4-3 | CASSQEVGTVPNQPQHF- | TRBJ1-5 |
| TRAV16 | CALQTGANNLFF | TRAJ36 | ||||
| TRAV13-1 | CATQTGANNLFF | TRAJ36 | TRBV9 | CASSVGR-SSYNEQFF | TRBJ2-1 | |
| TRAV24 | CASQTGANNLFF | TRAJ36 | TRBV4-1 | CASSQDPLTSGRGNEQFF | TRBJ2-1 | |
| ZNP1 | TRAV13-1 | CAASGANSGYALNF | TRAJ41 | TRBV30 | CAWSAQGETQYF | TRBJ2-5 |
| TRAV8-4 | CAVSGANSGYALNF | TRAJ41 | TRBV30 | CAWESGTRGNYGYTF | TRBJ1-2 | |
A
Shown are amino acid sequence comparisons of TCRs having single mismatched TRA junctions between IAR and PIT TCRs. IAR TCRs of the indicated specificities were used as reference sequences.
B
Bold font indicates a mismatch with the IAR reference sequence (top row of each pair).