Table 2.
Multivariable analysis of MGUS progression.
| Parameter | aHR | 95% Confidence Interval | P-value | |
|---|---|---|---|---|
| No Exposure | (reference) | |||
| High Exposure | 1.484 | 1.02-2.16 | 0.04 | |
| Medium Exposure | 1.054 | 0.89-1.25 | 0.55 | |
| Low Exposure | 0.833 | 0.50-1.40 | 0.49 | |
| MGUS Age | 0.97 | 0.96-0.98 | <0.0001 | |
| Gender | ||||
| Male | 0.84 | 0.51-1.37 | 0.49 | |
| Race | ||||
| Black | 1.23 | 1.07-1.42 | 0.004 | |
| BMI Category | ||||
| Obese | 1.29 | 1.06-1.57 | 0.012 | |
| Overweight | 1.24 | 1.01-1.51 | 0.041 | |
| Normal weight | (reference) | |||
| Underweight | 0.58 | 0.26-1.31 | 0.19 | |
| M-spike | ||||
| ≥1.5 g/dL | 4.37 | 3.62-5.26 | <0.0001 | |
| MGUS Type | ||||
| IgA | 1.53 | 1.28-1.83 | <0.0001 | |
| IgG | (reference) | |||
| CCI | 0.96 | 0.93-0.98 | 0.003 | |
Abbreviations: IG, immunoglobulin; BMI, body mass index; M-spike, monoclonal spike; mOS, median overall survival