Figure 2. Identification of distinct cholangiocyte clusters in ECO.
ECO from PSC (n=4) and non-PSC (n=4) patients were subjected to single cell RNA seq. A) UMAP plot visualizing eight distinct clusters termed Cluster (0) to (8), obtained by unsupervised clustering. Colors represent a unique cell population cluster as identified by transcriptional signature. B) Heatmap displaying the top 5 cluster marker genes for each unique cell population cluster. Colors indicate the expression of each gene in a cluster, when compared to all other cluster combined (Yellow = upregulation, Purple = downregulation).
