Figure 4. IL-17 response in PSC and non-PSC ECO.
PSC and non-PSC ECO were treated with vehicle or IL-17A (100ng/ml) for 24 hr. and subjected to single cell RNA seq. A) Dot plot displaying IL-17 receptor family expression represented as a pseudo bulk analysis. The size of the circle indicates the percentage of cells expressing each gene. B) UMAP plots visualizing the different clusters in PSC and non-PSC, and treatments (Vehicle and IL-17A). Colors represent unique cell population clusters as identified by transcriptional signature.
