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[Preprint]. 2023 Oct 3:rs.3.rs-3222344. [Version 1] doi: 10.21203/rs.3.rs-3222344/v1

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Effects of O-1602 on intravenous cocaine or nicotine self-administration (SA). A/B: Systemic administration of O-1602 failed to alter cocaine self-administration under FR1 or FR2 reinstatement schedules in Long-Evan rats (A) or wildtype mice (B). C/D: O-1602 dose-dependently inhibited nicotine SA under FR1 reinforcement as assessed by the total number of nicotine infusions (C) or the rate of nicotine infusions (D). E/F: O-1602 also inhibited nicotine SA under progressive-ratio (PR) reinforcement as assessed by the number of infusions (E) or break-point for nicotine SA (F). Pretreatment with CID 16020046 (CID), a selective GPR55 antagonist, blocked action produced by O-1602. *p<0.05, compared to the vehicle control group