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[Preprint]. 2023 Oct 18:rs.3.rs-3328953. [Version 1] doi: 10.21203/rs.3.rs-3328953/v1

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Primary human NK cells (NK-92 line) were treated with alcohol, indole, or recombinant TGFβ1 and NK cell function was assessed. (A) NK cell migration in response to the CCL2/CXCL12. (B-E) Percent viable K. pneumoniae 3 hrs. post co-culture with NK cells pre-treated with different compounds/inhibitors. (B) Ethanol dose dependent inhibition of bactericidal capacity. (C) Inhibition of bactericidal capacity via TGFβ1 and rescue of alcohol-mediated inhibition via indole. (D). Indole improves TGFβ1 mediated suppression of bactericidal capacity in a dose dependent manner. (E) NK cell bactericidal capacity mediated via alpha-defensin; p values are indicated in the figure by one-way ANOVA with Sidak’s multiple comparison. N = 3–6/group.