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. Author manuscript; available in PMC: 2023 Oct 26.
Published in final edited form as: Nature. 2023 Jun 28;619(7969):323–331. doi: 10.1038/s41586-023-06250-x

Extended Data Fig. 8 |. Genetic correlations with MS severity.

Extended Data Fig. 8 |

Shared genetic contribution obtained from cross-trait LDSC. Colors correspond to genetic correlation (rg) estimates (blue, negative; red, positive). An asterisk indicates a correlation that is significantly different from zero, based on two-sided P values calculated using LDSC (*FDR < 0.05, **FDR < 0.01). Full results are in Supplementary Table 17. Aging-GIP1 was constructed using principal component analysis to capture GWASs of healthspan, father lifespan, mother lifespan, longevity, frailty, and self-rated health85.