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. Author manuscript; available in PMC: 2023 Oct 26.
Published in final edited form as: Nature. 2023 Jun 28;619(7969):323–331. doi: 10.1038/s41586-023-06250-x

Extended Data Fig. 10 |. MS susceptibility PGS and longitudinal disability outcomes.

Extended Data Fig. 10 |

a, Adjusted mean EDSS scores over time by PGS quartile predicted from LMM analysis. Shaded ribbons indicate the standard error of the mean over time; P value from LMM. b, Covariate-adjusted cumulative incidence of 24-week confirmed disability worsening comparing individuals in the highest versus those in the lowest quartile of MS susceptibility PGS. c, Covariate-adjusted cumulative incidence of requiring a walking aid for the same groups of individuals. HR and two-sided P values were obtained from Cox proportional hazards models using imputed allele dosage (b–c; Methods). Across all analyses, the MS susceptibility PGS had no influence on longitudinal outcomes.