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. Author manuscript; available in PMC: 2023 Oct 26.
Published in final edited form as: Nature. 2023 Jun 28;619(7969):323–331. doi: 10.1038/s41586-023-06250-x

Extended Data Fig. 3 |. Replication of MS severity variants by center.

Extended Data Fig. 3 |

a, Genome-wide significant lead variant rs10191329. b, Suggestive lead variant rs149097173. Forest plots show successful replication of the two variants with minimal heterogeneity between centers as indicated by the Cochran’s Q and I2 statistics (n = 9,805 participants). ARMSS scores are rank-based inverse-normal transformed. Error bars represent 95% CIs. ARMSS, age-related multiple sclerosis severity; CI, confidence interval.