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. Author manuscript; available in PMC: 2023 Oct 26.
Published in final edited form as: Nature. 2023 Jun 28;619(7969):323–331. doi: 10.1038/s41586-023-06250-x

Table 1 |.

Variants associated with MS severity.

Chr. Position (bp) ID EA EAF R2 Effect (s.e.) P discovery P replication P combined Genes
2 71676999 rs10191329 A 0.17 0.97 0.089 (0.015) 9.7×10−9 0.021 3.6×10−9 DYSF–ZNF638
1 172370873 rs149097173 T 0.01 0.94 0.256 (0.056) 4.1×10−6 0.010 2.3×10−7 DNM3–PIGC

Effect on ARMSS score in MS patients. Two variants were genome-wide significant (bold) or suggestive in the discovery GWAS and confirmed in the replication population; two-sided P values were calculated using regression models. Pcombined represents the fixed-effects meta-analysis P value of the discovery and replication data. Chr., chromosome; bp, base pair (GRCh37); EA, effect allele; EAF, risk allele frequency; R2, imputation quality score; s.e., standard error.