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Kis of analogs and Kms of dGTP and dCTP substratesa
| Substrate | Km (nM) | Analog | Ki (nM) | Ki/Km |
|---|---|---|---|---|
| dGTP | 12.0 | BMS-200475–TP | 3.2 | 0.27 |
| dGTP | 13.1 | Lobucavir-TP | 4.86 | 0.37 |
| dCTP | 13.0 | 3TC-TP | 41.5 | 3.19 |
Values were calculated from four (BMS-200475-TP) and three (lobucavir-TP, 3TC-TP) independent experiments, respectively, in which baculovirus-derived HBV nucleocapsids were used as a polymerase source (35).
