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In vitro activities of ABT-378 and ritonavir against patient HIV isolates containing mutations conferring resistance to ritonavir
| Patient no. | Resistance mutations in sequence | EC50 (nM)a
|
|
|---|---|---|---|
| ABT-378 | Ritonavir | ||
| 129 | Baseline | 5 | 24 |
| V82T, I54V, A71A/V, M36M/I, K20K/R | 29 | 680 | |
| 131 | Baseline | 4 | 18 |
| V82A, I54I/V, M36I, K20K/R | 52 | 730 | |
| 224 | Baseline | 6 | 29 |
| V82S, I54V/M, M36M/I, K20K/R, L33L/F | 52 | 496 | |
EC50s represent the means of two or more determinations.
