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. 2023 Aug 28;10(30):2303006. doi: 10.1002/advs.202303006

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© 2023 The Authors. Advanced Science published by Wiley‐VCH GmbH

This is an open access article under the terms of the http://creativecommons.org/licenses/by/4.0/ License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Evaluation of Lap@C‐C adjuvanted DC vaccine against hepatitis B virus (HBV). a) Construction schedule of visualized HBV clearance mouse model. b, c) Representative images and statistical analysis of fluorescence intensity in the mouse liver after hydrodynamic injection of pGL3/Fluc‐HBV1.2. d, e) Assay of serum HBV DNA copy number and hepatitis B surface antigen (HBsAg) titers. f) Serum alanine aminotransferase activity in mice. g) Infiltration of CD8⁺ T cells into the liver detected by immunohistochemical staining. Data represent mean ± SD (n = 5). *P < 0.05 DC_Lap@C‐C group compared with the DC_Naïve group. #P < 0.05 DC_Lap@C‐C group compared with the DC_C‐C group. Representative results from two or three replicates are shown.