TABLE 3.

Inhibition of wild-type and mutant neuraminidases by analogs of GS 4071

Compound	R	IC50 (nM)a		Fold increase in IC50
		Wild type	Mutant
GS 4071		0.2	6,500	32,500
GS 4047		0.7	8,500	12,145
GS 4048		0.8	22,500	28,125
GS 3768		60	14,000	235
GS 4926		290	21,000	70
GS 4993		750	44,500	60
GS 4093		21	17,500	835
GS 4383		0.09	6,500	72,220

^aData shown are average values from two independent experiments using 50 μM MUNANA as substrate.