TABLE 1.

In vitro susceptibilities of 1,300 Candida bloodstream isolates to BMS-207147, Sch 56592, and voriconazole versus fluconazole and itraconazole

Organism (no. of isolates) and antifungal agent	MIC (μg/ml)
	Range	50% of isolates	90% of isolates
C. albicans (660)
BMS-207147	0.008–>8.0	0.008	0.03
Sch 56592	0.008–>8.0	0.03	0.06
Voriconazole	0.008–>8.0	0.015	0.06
Fluconazole	0.12–>128	0.25	1.0
Itraconazole	0.015–>8.0	0.06	0.25
C. parapsilosis (221)
BMS-207147	0.008–4.0	0.03	0.12
Sch 56592	0.008–>8.0	0.12	0.12
Voriconazole	0.008–2.0	0.03	0.12
Fluconazole	0.12–64	1.0	2.0
Itraconazole	0.015–2.0	0.12	0.5
C. glabrata (217)
BMS-207147	0.008–>8.0	0.5	4.0
Sch 56592	0.015–>8.0	1.0	4.0
Voriconazole	0.03–8.0	0.5	2.0
Fluconazole	0.25–>128	16	64
Itraconazole	0.06–>8.0	1.0	4.0
C. tropicalis (139)
BMS-207147	0.008–>8.0	0.03	0.25
Sch 56592	0.015–>8.0	0.06	0.25
Voriconazole	0.008–>8.0	0.06	0.25
Fluconazole	0.25–>128	0.5	2.0
Itraconazole	0.03–>8.0	0.12	0.5
C. krusei (33)
BMS-207147	0.06–2.0	0.25	0.5
Sch 56592	0.12–1.0	0.5	0.5
Voriconazole	0.06–4.0	0.5	1.0
Fluconazole	8.0–128	64	64
Itraconazole	0.12–2.0	1.0	2.0
Candida spp. (30)a
BMS-207147	0.008–8.0	0.12	0.5
Sch 56592	0.03–>8.0	0.12	0.5
Voriconazole	0.008–8.0	0.06	0.5
Fluconazole	0.25–128	2.0	8.0
Itraconazole	0.03–>8.0	0.25	1.0
All organisms (1,300)
BMS-207147	0.008–>8.0	0.03	0.5
Sch 56592	0.008–>8.0	0.06	1.0
Voriconazole	0.008–>8.0	0.03	0.5
Fluconazole	0.12–>128	0.5	16
Itraconazole	0.015–>8.0	0.12	1.0

^aIncludes seven C. lusitaniae, seven C. guilliermondii, three C. famata, two C. rugosa, one C. lipolytica, one C. lambica, and nine Candida sp. isolates.