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. 2023 Sep 21;24(11):1825–1838. doi: 10.1038/s41590-023-01631-w

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 8 — a, Effect of LPS treatment on homeostatic strain-specific genes. Left panel shows differential expression of transcripts in LPS treated C57BL/6J and BALB/cJ Kupffer cells. Select genes that display differential expression under LPS treatment are shown in red, while genes that are non-specific are shown in black. Right panel shows parental strain-specific genes overlayed onto strain-specific expression under LPS treatment. b, Motif enrichment in strain-specific trans peaks following LPS treatment. c, De novo motif enrichment of C57BL/6J and BALB/cJ specific accessible enhancers following LPS treatment. d, De novo motif enrichment of C57BL/6J and BALB/cJ specific trans enhancers following LPS treatment. P values in c and d calculated under binomial distribution as implemented by HOMER.