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. 2023 Oct 16;24(11):1947–1959. doi: 10.1038/s41590-023-01641-8

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© The Author(s) 2023, corrected publication 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a, Mean frequency of each T cell subset within the T cell compartment in children and older adults, grouped by CMV infection status. b,c, 3WNN UMAP plots colored according to cell density in each age category (b; green, greater in children; orange, greater in older adults) or in each CMV infection status group (c; blue, greater in CMV-negative donors; yellow, greater in CMV-positive donors). d,e, Number of DEGs (d) and DAPs (e) within each T cell subset by age (green, higher in children; orange, higher in older adults) or CMV infection status (blue, higher in CMV-negative donors; yellow, higher in CMV-positive donors). f, Gene set enrichment analysis (GSEA) of each T cell subset, comparing age- or CMV infection status-related differences. A false discovery rate (FDR) of <0.05 was considered significant. Dot size corresponds to the percentage of leading edge genes enriched in the indicated pathway. Dot color corresponds to the normalized enrichment score (NES). g, Shared TF motif enrichment based on DAPs between age groups or CMV infection status within each T cell subset. No significant motifs were detected for CMV comparisons. Both the size and color of each point correspond to the P_adj of enrichment determined by hypergeometric testing, with green indicating higher accessibility in pediatric donors and orange indicating higher accessibility in adult donors. NFE2, nuclear factor, erythroid 2; CBFβ, core-binding factor subunit β; BCL11A/BCL11B, B-cell lymphoma/leukemia 11A/B; RUNX1/RUNX2/RUNX3, Runt-related TF 1/2/3; IRF1/IRF2/IRF3/IRF4/IRF8/IRF9, IFN regulatory factor 1/2/3/4/8/9; PRDM1, PR domain zinc finger protein 1; ZNF683, zinc finger protein 683; BATF, basic leucine zipper TF, ATF-like; BACH1/BACH2, broad complex-tramtrack-bric a brac and cap‘n’collar homology 1/2; STAT2, signal transducer and activator of transcription 2; JDP2, JUN dimerization protein 2; SMARCC, SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin subfamily C.

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