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. 2023 Oct 26;13:18341. doi: 10.1038/s41598-023-44050-5

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Evaluation of transmembrane exo-proteins in plasma samples using ExoProfile chips. (a) Image of an ExoProfile chip consisting of 8 nanopatterned parallel channels for EV capture. (b) Quantification of transmembrane exo-protein biomarkers on captured CD81 + EVs for HGSOC (n = 10) and healthy control (n = 20) (dotted line signifies background fluorescence from a negative control channel labeled as BKG). FOLR1 was included as a previous positive control for HGSOC³². p-values were calculated using Mann–Whitney U test. (c) Area under the curve plot of receiver operating characteristic analyses for all the six markers and FOLR1 are shown.