Table 1.

Statistical analysis for each exo-protein biomarker including the most sensitive linear marker combination of IGSF8 and ITGA5 on the ExoProfile chip.

Exo-protein	AUC	Standard error	CI_lower	CI_upper	p-value-1t	Sensitivity at 99.8% specificity	PPV
IGSF8	0.895	0.064	0.770	1.000	2.77 × 10–4	0.300	0.057
ITGA2	0.885	0.064	0.759	1.000	3.82 × 10–4	0.400	0.074
MYOF	0.850	0.080	0.692	1.000	1.12 × 10–3	0.400	0.074
ACSL4	0.915	0.052	0.813	1.000	1.42 × 10–4	0.600	0.107
ITGB3	0.980	0.022	0.938	1.000	1.33 × 10–4	0.900	0.153
ITGA5	0.950	0.037	0.878	1.000	4.12 × 10–5	0.600	0.107
FOLR1	0.925	0.047	0.832	1.000	1.01 × 10–4	0.600	0.107
Linear combination of IGSF8 & ITGA5	0.990	0.020	0.964	1.000	1.33 × 10–5	0.800	0.138