Table 3.
Biochemistry analysis of serum from Pkd1Oc-cKO or/and Wwtr1Oc-cKO mice
| Genotype | Wild-type | Pkd1Oc-cKO | Wwtr1Oc-cKO | Pkd1/Wwtr1Oc-cKO | P-value |
|---|---|---|---|---|---|
| Urea nitrogen/(mg·dL−1) | 19 ± 5 | 22 ± 5 | 21 ± 6 | 22 ± 4 | 0.723 6 |
| Calcium/(mg·dL−1) | 10.3 ± 0.9 | 10.4 ± 1.3 | 10.2 ± 1.5 | 9.4 ± 0.9 | 0.399 0 |
| Phosphorus/(mg·dL−1) | 10.1 ± 1.9 | 10.4 ± 1.4 | 9.8 ± 2.4 | 10.3 ± 1.5 | 0.935 5 |
| Osteocalcin (ng/mL) | 17.5 ± 3.5 | 3.4 ± 0.7*** | 10.7 ± 2.6*** | 1.0 ± 0.8#,&&& | <0.000 1 |
| TRAP/(U·L−1) | 10.8 ± 1.3 | 7.6 ± 0.6*** | 12.2 ± 1.9* | 9.8 ± 1.1##,&& | <0.000 1 |
| FGF23/(pg·mL−1) | 117 ± 32 | 79 ± 16* | 116 ± 35 | 46 ± 16#,&&& | 0.070 4 |
| Leptin/(pg·mL−1) | 836 ± 200 | 2 636 ± 759*** | 2 649 ± 915*** | 1 793 ± 600###,&& | <0.000 1 |
Data are mean ± S.D. from 6 serum samples of wild-type control, Pkd1Oc-cKO, Wwtr1Oc-cKO, and Pkd1/Wwtr1Oc-cKO mice. *P < 0.05, **P < 0.01, ***P < 0.001 compared with wild-type mice, #P < 0.05, ##P < 0.01, ###P < 0.001 compared with Wwtr1Oc-cKO mice, and &P < 0.05, &&P < 0.01, &&&P < 0.001 compared with Pkd1Oc-cKO mice, respectively. P values were determined by 1-way ANOVA with Tukey’s multiple-comparisons test