Table 4.

Mechanosensing, osteogenic, and adipogenic gene-expression profiles that respond to mechanical loading in wild-type and double Pkd1/Wwtr1^Oc-cKO mice

Gene	Wild-type (no load)	Wild-type (loaded)	Pkd1/Wwtr1Oc-cKO (no load)	Pkd1/Wwtr1Oc-cKO (loaded)
Wnt10b	1.00 ± 0.32	1.74 ± 0.62**	1.00 ± 0.31	0.94 ± 0.31
c-Jun	1.00 ± 0.27	1.72 ± 0.41***	1.00 ± 0.18	0.95 ± 0.29
c-Fos	1.00 ± 0.22	2.04 ± 0.66***	1.00 ± 0.24	0.92 ± 0.29
Axin-2	1.00 ± 0.16	1.54 ± 0.25***	1.00 ± 0.19	0.92 ± 0.33
PTGS2	1.00 ± 0.16	3.34 ± 1.05***	1.00 ± 0.22	1.15 ± 0.17
Runx2-II	1.00 ± 0.28	1.94 ± 0.54***	1.00 ± 0.19	0.92 ± 0.19
FzD2	1.00 ± 0.26	1.92 ± 0.47***	1.00 ± 0.26	0.93 ± 0.32
Osteocalcin	1.00 ± 0.34	5.26 ± 1.58***	1.00 ± 0.36	1.77 ± 0.41
Alp	1.00 ± 0.32	2.82 ± 1.05***	1.00 ± 0.30	0.92 ± 0.29
Collagen I	1.00 ± 0.25	4.93 ± 1.59***	1.00 ± 0.58	1.01 ± 0.33
Dmp1	1.00 ± 0.32	1.83 ± 0.29***	1.00 ± 0.34	1.03 ± 0.27
PPARγ2	1.00 ± 0.40	0.24 ± 0.12***	1.00 ± 0.21	0.86 ± 0.28
aP2	1.00 ± 0.25	0.57 ± 0.14***	1.00 ± 0.18	0.89 ± 0.17
Lpl	1.00 ± 0.32	0.35 ± 0.11***	1.00 ± 0.30	0.88 ± 0.30

Data are mean ± S.D. from 6 tibiae of wild-type control and Pkd1/Wwtr1^Oc-cKO mice and expressed as the fold changes relative to the housekeeping gene eEF1a1 subsequently normalized to control or Pkd1/Wwtr1^Oc-cKO no load tibiae. *, **, *** indicates significant difference from wild-type or Pkd1/Wwtr1^Oc-cKO no load control at P < 0.05, P < 0.01, P < 0.001