Table 5.

Gene expression profiles in bone from MS2-treated wild-type control and Pkd1/Wwtr1^Oc-cKO mice

Gene	Wild-type (Vehicle)	Wild-type (MS2)	Pkd1/Wwtr1Oc-cKO (Vehicle)	Pkd1/Wwtr1Oc-cKO (MS2)
Pkd1	1.00 ± 0.13	0.94 ± 0.15	1.00 ± 0.37	1.03 ± 0.28
Wwtr1	1.00 ± 0.32	1.01 ± 0.32	1.00 ± 0.40	0.82 ± 0.19
Runx2-II	1.00 ± 0.19	1.79 ± 0.52**	1.00 ± 0.32	1.03 ± 0.28
Osteocalcin	1.00 ± 0.24	1.68 ± 0.24***	1.00 ± 0.57	0.86 ± 0.61
ALP	1.00 ± 0.14	1.56 ± 0.23***	1.00 ± 0.52	1.09 ± 0.55
Dmp1	1.00 ± 0.18	1.45 ± 0.17***	1.00 ± 0.33	1.02 ± 0.48
OPG	1.00 ± 0.38	1.10 ± 0.37	1.00 ± 0.30	1.18 ± 0.33
RankL	1.00 ± 0.30	0.57 ± 0.15*	1.00 ± 0.50	0.99 ± 0.33
Trap	1.00 ± 0.26	0.56 ± 0.10*	1.00 ± 0.58	0.93 ± 0.28
PPARγ2	1.00 ± 0.43	0.59 ± 0.11*	1.00 ± 0.47	1.06 ± 0.18
aP2	1.00 ± 0.22	0.60 ± 0.26*	1.00 ± 0.22	1.07 ± 0.12
Lpl	1.00 ± 0.28	0.63 ± 0.12*	1.00 ± 0.40	0.95 ± 0.39
Wnt1	1.00 ± 0.30	3.02 ± 0.98***	1.00 ± 0.60	0.97 ± 0.40
Wnt10b	1.00 ± 0.15	1.52 ± 0.25***	1.00 ± 0.40	1.12 ± 0.21
FzD2	1.00 ± 0.26	3.36 ± 1.56***	1.00 ± 0.30	0.95 ± 0.18
c-Fos	1.00 ± 0.20	1.47 ± 0.34*	1.00 ± 0.22	1.00 ± 0.27
c-Jun	1.00 ± 0.23	1.74 ± 0.24***	1.00 ± 0.29	0.84 ± 0.20
Axin-2	1.00 ± 0.22	2.57 ± 1.02**	1.00 ± 0.16	0.92 ± 0.17
PTGS2	1.00 ± 0.35	2.25 ± 0.78**	1.00 ± 0.26	0.90 ± 0.22
eNOS	1.00 ± 0.45	3.09 ± 0.68***	1.00 ± 0.13	1.03 ± 0.22

Data are mean ± S.D. from 6 tibias of wild-type control and Pkd1/Wwtr1^Oc-cKO mice and expressed as the fold changes relative to the housekeeping gene eEF1a1 subsequently normalized to control or Pkd1/Wwtr1^Oc-cKO no load tibias. *, **, *** indicates significant difference from wild-type control at P < 0.05, P < 0.01, P < 0.001