Dupont 1984.

Methods	Randomized, double‐blind, placebo‐controlled, cross‐over study. Each treatment period lasted 4 weeks
Participants	10 participants Mean age (range): 54.4 years (45‐62) Inclusion criteria: ambulatory DBP 95‐115 mmHg
Interventions	Nadolol 80 mg once daily, placebo
Outcomes	Mean ABP, HR, CO, GFR, renal blood flow, renal vascular resistance
Notes	SBP and DBP data were not reported. Only HR data were relevant to this review
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	No information
Allocation concealment (selection bias)	Unclear risk	No information
Blinding (performance bias and detection bias) All outcomes	High risk	No information
Incomplete outcome data (attrition bias) Primary and secondary outcomes	High risk	SBP and DBP data were not reported
Selective reporting (reporting bias)	High risk	SBP and DBP data were not reported