Pearson 1979.

Methods	Randomized, double‐blind, placebo‐controlled, cross‐over study. Without washout period, participants were randomized to treatment upon entry. Each treatment period lasted for 6 weeks
Participants	16 participants (8 males) Mean age: 54 years Inclusion criteria: DBP ≥ 100 mmHg with single‐drug therapy Exclusion criteria: angina, MI, heart failure, stroke, COPD, gout, women of child‐bearing potential or using oral contraceptive pills
Interventions	Propranolol 80 mg twice daily, tienilic acid 250 mg every morning, propranolol 80 mg plus tienilic acid 250 mg, placebo
Outcomes	SBP, DBP, HR, adverse effects
Notes
Risk of bias
Bias	Authors' judgement	Support for judgement
Random sequence generation (selection bias)	Unclear risk	No information
Allocation concealment (selection bias)	Unclear risk	No information
Blinding (performance bias and detection bias) All outcomes	High risk	"The tablets in each treatment period were identical in number and appearance", but pulse rate would unblind BP measurement
Incomplete outcome data (attrition bias) Primary and secondary outcomes	Unclear risk	No information
Selective reporting (reporting bias)	High risk	SEM were extracted from figures. WDAE not reported