TABLE 3.

Baseline metoprolol concentration and time to first fall.

	N	Model 1 c HR (95%CI)	p‐value	N	Model 2 d HR (95%CI)	p‐value
Continuous concentration	316	1.003 (1.00–1.01)	.004*
Concentration divided on median a	316	1.550* (1.11–2.16)	.01*
Concentrations divided in four quartiles b
Lowest quartile	316	Ref.		243	Ref.
Second quartile		0.767 (0.47–1.27)	.300		0.645 (0.37–1.13)	.127
Third quartile		1.271 (0.81–2.00)	.299		1.099 (0.66–1.84)	.720
Highest quartile		1.470 (0.93–2.32)	.097		1.073 (0.63–1.84)	.798

Note: Data presented as hazard ratio with a 95% confidence interval. Number of events model 1: n = 154. Number of events model 2: n = 118.

Abbreviations: N, number of analyzed plasma concentrations; CI, confidence interval.

^a Median concentration selective beta‐blocker: 16.95 ng/mL.

^b Concentration selective beta‐blocker 25th percentile: 8.61 ng/mL; 75th percentile: 46.5 ng/mL.

^c Model 1 was adjusted for age and gender.

^d Model 2 was adjusted for age, gender, eGFR, and CV disease. No model 2 was constructed for the continuous and binary metoprolol concentration because none of the added variables changed the outcome more than 10%.

^* p‐value ≤.05.