Table 1.
Summary of ferroptosis inhibitors
| Compound | CAS no. | Target | Mechanism | Ref. PMID |
| Deferiprone | 30652-11-0 | Iron | Reduces intracellular iron | 22632970 |
| Deferoxamine | 138-14-7 | Iron | Reduces intracellular iron | 22632970 |
| Curcumin | 458-37-7 | Iron; Keap1 | Reduces iron accumulation and activates | 30736288 |
| NRF2 signalling pathway | 31034781 | |||
| Ferrostatin-1 | 347174-05-4 | Lipid ROS | Inhibits lipid peroxidation | 31571665 |
| Liproxstatin-1 | 950455-15-9 | Lipid ROS | Inhibits lipid peroxidation | 28386601 |
| THN | 18512-30-6 | Lipid ROS | Reduces intracellular ROS | 28386601 |
| Rosiglitazone | 122320-73-4 | ACSL4 | Suppresses the ACSL4 protein and reduces intracellular ROS | 35038927 |
| Pioglitazone | 111025-46-8 | ACSL4 | Suppresses the ACSL4 protein and reduces intracellular ROS | 35038927 |
| Troglitazone | 97322-87-7 | ACSL4 | Suppresses the ACSL4 protein and reduces intracellular ROS | 27842070 |
ACSL4, acyl-CoA synthetase long chain family member 4; NRF2, nuclear factor erythroid 2-related factor 2; Ref, reference; ROS, reactive oxygen species; THN, tetrahydronaphthyridinols.