Table 1.

Overview of the QotM challenges

QotM Challenge	SME	Challenge Question
QotM #1	PhD; Senior Scientist, molecular toxicology and genomics	What mechanism might explain the strong association between valproic acid and ALAS1 in in vitro liver models?
QotM #2	MD, PhD; Professor, molecular and cell biology, theoretical biology	What mechanism might explain the association between high levels of β-sitosterol and severe coronavirus infection?
QotM #3	MD; Professor, medicine, toxicology, and experimental therapeutics	What biological mechanisms might explain the observation that CBD is generally safe except in patients taking valproic acid?
QotM #4	MD; Professor, endocrinology, diabetes, and metabolism	What is the molecular target of an antidiabetic small molecule?*
QotM #5	MD; Practicing Physician and Clinical Professor, internal medicine and rheumatology	What are risk factors for progressing from PsO to PsA? More specifically, in a population of patients with PsO, what risk factors could be used to recruit a cohort of patients with increased risk for new onset of PsA within three years?
QotM #6	MD; Vice President for Research and Clinical Management MD; Professor, neurosciences and pediatrics MD; Fellow, genetics	Given a mutation in gene ATP1A3 and a case description of associated phenotypes, can Translator propose new therapies?**

CBD = cannabidiol; PsA = psoriatic arthritis; PsO = psoriasis; QotM = question-of-the-month.

^*Note that this question was abstracted here due to the proprietary nature of the anti-diabetic small molecule.

^**Note that the specific phenotypes varied by clinical case; however, the following phenotypes were generally shared across cases, albeit with varying severity: nystagmus; episodic hemiplegia; dystonia; tremors; global developmental delay; hypotonia; seizures; gastroesophageal reflux; paroxysmal dystonia; and muscle weakness.