Table 3. Balance of Factors for the Overlap Population After Propensity Score Weighting.
| Factor | % | |
|---|---|---|
| Lansoprazole effective sample size (n = 3586.4) | Other PPI effective sample size (n = 15 425.2) | |
| Age, mean (SD), y | 73.6 (16.1) | 73.6 (15.8) |
| Sex | ||
| Female | 48.1 | 48.1 |
| Male | 51.9 | 51.9 |
| From a long-term care home | 12.6 | 12.6 |
| Hospital sites | ||
| A | 13.3 | 13.3 |
| B | 0 | 0 |
| C | 12.2 | 12.2 |
| D | 10.4 | 10.4 |
| E | 1.4 | 1.4 |
| F | 5.3 | 5.3 |
| G | 0.3 | 0.3 |
| H | 3.5 | 3.5 |
| I | 1.4 | 1.4 |
| J | 14.5 | 14.5 |
| K | 18.9 | 18.9 |
| L | 9.9 | 9.9 |
| M | 9.0 | 9.0 |
| Admission year | ||
| 2015 | 6.7 | 6.7 |
| 2016 | 10.5 | 10.5 |
| 2017 | 14.9 | 14.9 |
| 2018 | 17.3 | 17.3 |
| 2019 | 15.4 | 15.4 |
| 2020 | 24.0 | 24.0 |
| 2021 | 11.3 | 11.3 |
| Admission season | ||
| Winter | 26.0 | 26.0 |
| Spring | 26.2 | 26.2 |
| Summer | 24.5 | 24.5 |
| Autumn | 23.3 | 23.3 |
| Modified Charlson comorbidity index, mean (SD) | 1.3 (1.7) | 1.3 (1.8) |
| Risk factors for ventricular arrhythmia | ||
| Coronary artery disease | 2.5 | 2.5 |
| Prior myocardial infarction | 1.9 | 1.9 |
| Cardiomyopathy | 1.1 | 1.1 |
| Heart failure | 12.8 | 12.8 |
| Prior ventricular arrhythmia | 0.2 | 0.2 |
| Chronic kidney disease | 5.6 | 5.6 |
| Abnormal serum potassium level at admission | 45.1 | 45.1 |
| mLAPS score, mean (SD) | 26.5 (18.3) | 26.5 (18.1) |
| ICU admission prior to ceftriaxone and PPI | 6.2 | 6.2 |
| Admitting main responsible diagnosis | ||
| Pneumonia | 6.9 | 6.9 |
| Urinary tract infection | 5.7 | 5.7 |
| Aspiration | 8.0 | 8.0 |
| COPD with lower respiratory tract infection | 3.2 | 3.2 |
| Congestive heart failure | 3.0 | 3.0 |
| COPD exacerbation | 1.5 | 1.5 |
| Sepsis | 2.9 | 2.9 |
| COVID-19 infection | 3.0 | 3.0 |
| Cellulitis involving limb | 0.5 | 0.5 |
| Acute kidney failure | 1.5 | 1.5 |
| Medications taken during ceftriaxone therapy | ||
| Quinolones | 3.8 | 3.8 |
| Macrolides | 2.5 | 2.5 |
| Cardiac medications associated with ventricular arrhythmia | 4.5 | 4.5 |
| Other medications associated with ventricular arrhythmia | 17.1 | 17.1 |
Abbreviations: COPD, chronic obstructive pulmonary disease; ICU, intensive care unit; mLAPS, modified Laboratory-Based Acute Physiology Score; PPI, proton pump inhibitor.