Figure 2.

PRMT1 downregulation inhibits cell proliferation and migration and promotes cell apoptosis in TC. (A and B) RT-qPCR and western bolting were used to determine the expression of PRMT1 in 8505C cells following various treatments. (C and D) CCK-8 and colony formation assays were used to assess cell viability and proliferation, respectively, of treated 8050C cells. (E) Flow cytometry was used to determine apoptosis of treated 8505C cells. (F and G) Wound healing (magnification, ×100) and Transwell (magnification, ×200) assays were used to assess cell migration of the treated 8505C cells. *P<0.05, **P<0.01 vs. si-NC; ^#P<0.05, ^##P<0.01 vs. si-PRMT1; ^{^^}P<0.01 vs. 10 µM AMI-1. PRMT1, protein arginine methyltransferase 1; TC, thyroid carcinoma; si-NC, small interfering RNA negative control.