Optimization of the reaction conditions for the synthesis of the triazolo[2,1-b]quinazolinone derivative of 4-chlorobenzaldehyde catalyzed by NGPU.

Entry	Catalyst (mol%)	Solvent	Temperature (°C)	Time (min)	Conversion (%)
1	NGPU (2)	—	120	40	100
2	NGPU (3)	—	120	40	Mixture of products
3	NGPU (4)	—	120	20	100
4	NGPU (8)	—	120	43	100
5	NGPU (8)	—	100	40	Not completed
6	NGPU (4)	—	70	56	Not completed
7	NGPU (4)	EtOH	Reflux	50	Not completed
8	NGPU (4)	CH3CN	Reflux	50	Not completed
9	NGPU (4)	H2O	Reflux	50	Not completed
10	Glucose/pregabalin/urea (4) 1 : 1 : 5	—	120	35	100
11	Glucose/pregabalin/urea (4) 3 : 1 : 5	—	120	40	100
12	Pregabalin (4)	—	120	100	Not completed
13	Glucose (4)	—	120	100	Not completed
14	Urea (4)	—	120	100	Mixture of products
15	—	—	120	100	Trace