Figure 3.

Enriched terms for LV DEGs in the high-dose vs. HCM comparison. Enrichment plots for GO CC (A), GO BP (B,C), and KEGG pathway (D) term analyses are presented for down- (blue box) and upregulated (pink box) DEGs. The y-axis depicts identified enriched terms, whereas the x-axis depicts the terms’ significance (−log10[FDR]). The terms are sorted according to statistical significance; the top-most terms on the y-axis constitute the most statistically significant of terms. The size of individual points depicts the total number of genes binned to a given enriched term; high or low fold enrichment is represented by red or blue coloring, respectively. Abbreviations: HCM = hypertrophic cardiomyopathy, LV = left ventricle, GO = gene ontology, CC = cellular components, BP = biological processes, UR = upregulated, DR = downregulated, DEG = differentially expressed gene(s).