Table 3.
Congruent transcript and protein expression of differentially expressed genes/peptides in LV and IVS tissues. The total number of genes/peptides congruently differentially expressed in LV and IVS tissues are presented for each group comparison. Bolded gene symbols represent shared genes/peptides between LV and IVS tissues. * Under-/overabundance was assigned respective to the asterisk-marked groups in the comparison column. Abbreviations: HCM = hypertrophic cardiomyopathy, LV = left ventricle, IVS = interventricular septum.
Comparison | LV | IVS | ||
---|---|---|---|---|
Underexpression | Overexpression | Underexpression | Overexpression | |
Low-Dose * vs. HCM | CES2, SERPINB2 (n = 2) (n = 0) |
ANKRD1, ANKRD2, ASPN, DPYSL3, FBLN5, FHL1, LYPLA1, MSN, MYL1, PTGFRN, TGFBI, XIRP2 (n = 12) (n = 0) |
- (n = 0) (n = 0) |
- (n = 0) (n = 0) |
High-Dose * vs. HCM | AS3MT, PHOSPHO1 (n = 2) (n = 0) |
- (n = 0) (n = 0) |
- (n = 0) (n = 0) |
- (n = 0) (n = 0) |
All Doses * vs. HCM | - (n = 0) (n = 0) |
ASPN, COL6A3, FBLN5, TGFBI (n = 4) (n = 1) |
- (n = 0) (n = 0) |
FBLN5 (n = 1) (n = 1) |
Low- * vs. High-Dose | - (n = 0) (n = 0) |
- (n = 0) (n = 0) |
- (n = 0) (n = 0) |
- (n = 0) (n = 0) |