Table 1.
ToxCast and Chemical Activity Summary for OCPs. Organochlorine pesticides depicted in the table have significant estrogenic and anti-androgenic effects.
| Chemical | MODEL | RECEPTOR | AGONIST | ANTAGONIST | BINDING |
|---|---|---|---|---|---|
| Dieldrin | ToxCast Pathway Model (AUC) | Androgen | 0.00 | 4.15e-2 | - |
| ToxCast Pathway Model (AUC) | Estrogen | 1.81e-2 | 0.00 | - | |
| COMPARA (Consensus) | Androgen | Inactive | Active | Inactive | |
| CERAPP Potency Level (From Literature) | Estrogen | - | Inactive (Inactive) | Active (NaN) | |
| CERAPP Potency Level (Consensus) | Estrogen | Inactive (Inactive) | Inactive (Inactive) | Inactive (Inactive) | |
| DDT | ToxCast Pathway Model (AUC) | Androgen | 0.00 | 6.42e-2 | - |
| ToxCast Pathway Model (AUC) | Estrogen | 0.190 | 0.00 | - | |
| COMPARA (Consensus) | Androgen | Inactive | Active | Active | |
| CERAPP Potency Level (From Literature) | Estrogen | Active (Weak) | - | Active (Weak) | |
| CERAPP Potency Level (Consensus) | Estrogen | Active (VeryWeak) | Active (Moderate) | Active (VeryWeak) | |
| Methoxychlor | ToxCast Pathway Model (AUC) | Androgen | 0.00 | 4.29e-2 | - |
| ToxCast Pathway Model (AUC) | Estrogen | 0.254 | 0.00 | - | |
| COMPARA (Consensus) | Androgen | Inactive | Active | Active | |
| CERAPP Potency Level (From Literature) | Estrogen | Active (Weak) | - | Active (Weak) | |
| CERAPP Potency Level (Consensus) | Estrogen | Active (VeryWeak) | Active (Weak) | Active (VeryWeak) |