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Factors involved in the development of oxidative stress after brain damage in newborns and the consequences. Strategic biomarkers are shown in gray shading. CAT: catalase; ER: endoplasmic reticulum; GPx: glutathione peroxidases; GSH: reduced glutathione; GSSG: glutathione bisulfide; MDA: malondialdehyde; 4-HNE: 4-hydroxynonenal; NOS: nitric oxide synthase; 8-OHdG: 8-hydroxy-deoxyguanosine; PUFA: poli-unsaturated fatty acids; SOD: superoxide dismutase; XO: xanthin oxidase.
