Figure 4.

Relationship between protein carbonylation determined using Oxyblot and biomarkers of inflammation and blood–brain barrier integrity assessed using Western blot in brain samples obtained five days after induction of intraventricular hemorrhage (IVH) by paraventricular injection of Chlostridium collagenase in 1-day-old rats. Simple linear regression ((A): y = 0.4809 × X + 55.84, R² = 0.33, p = 0.008; (B): y = 0.1577 × X + 87.29, R² = 0.44, p = 0.009; (C): y = 0.5466 × X + 38.61, R² = 0.57, p < 0.0001; (D): y = −0.2535 × X + 126.5, R² = 0.22, p = 0.04). NFkB: nuclear factor k B; TNFa: tumor necrosis factor a; MMP-9: matrix metalloproteinase 9; Mfsd2a: major facilitator superfamily domain-containing protein 2a. The figures show results from analyses carried out on data obtained from the study described in reference [29].