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A schematic representation of the biochemical signaling pathways involved in the induction of pathologic conditions such as acute lung injury, inflammation, autophagy, and osteoarthritis. Lycorine inhibits the pathway, as indicated by the arrows. HMGB1, high-mobility group box1; TLRs, toll-like receptors; NF-κB, nuclear factor kappa B; JNK, c-Jun N-terminal protein kinase; IL1β, interleukin 1β; TNF-α, tumor necrosis factor α.
