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. 2023 Oct 14;12(10):1538. doi: 10.3390/antibiotics12101538

Table 5.

Distribution of MIC of tested quinolones and amino acid substitutions in gyrA gene in quinolone-resistant Gemella isolates.

Strain n MIC (μg/mL) GyrA Amino Acid Substitutions a
Levofloxacin Moxifloxacin
Gemella morbillorum 2 >128 >2 Ser83 > Leu83 (n = 2)
GH group 9 128–>128 >2 Ser83 > Phe83 (n = 7), Ser83 > Tyr83 (n =2)
Gemella taiwanensis 8 128–>128 >2 Ser83 > Phe83 (n = 7), Ser83 > Tyr83 (n = 1)
Gemella sanguinis 2 128–>128 >2 Ser83 > Phe83 (n = 2)

a gyrA-Ser83 Leu: serine to leucine at codon 83; Ser83 Phe: serine to phenylalanine at codon 83; Ser83 Tyr; serine to tyrosine at codon 83.